A recent article from Leo Wan's group was promoted to the cover of the journal Advanced Biology. The title of the article is "Cell Chirality as a Novel Measure for Cytotoxicity" and the authors are Haokang Zhang and Leo Q. Wan.
The article can be found here:
and a brief summary of the abstract is shown below:
This article reviews the characterization of cellular chirality or handedness which can be used for cytotoxicity assessment. The cells display directional alignment within well-confined geometric boundaries in normal conditions, such as ring-shaped micropatterns. In toxic environments, cell alignment may exhibit a reversed bias or become randomized. This new type of assay offers an overall functional assessment of the health of the cell.