Posted June 30, 2015
The RPI Board of Trustees has approved Guohao Dai's promotion to Associate Professor with tenure.
Guohao graduated from Beijing University, China with B.S. in Mechanical Engineering and M.S. in Biomechanics, where he performed research on cardiovascular system modeling and the dynamic coupling of left ventricle and systemic arteries. After that, he came to the Massachusetts Institute of Technology and subsequently joined the Harvard-MIT Division of Health Science’s Medical Engineering and Medical Physics program. During his Ph.D. studies, he did research in Fluid Mechanics Laboratory at MIT and Vascular Surgery Research Laboratory at Massachusetts General Hospital. There, he developed a biomechanical model to analyze venous blood flow and tissue mechanics in the lower leg, and optimized the design of external pneumatic compression (EPC) device for better deep vein thrombosis (DVT) prophylaxis. Then, he completed Post-doctoral training in Dr. Michael Gimbrone’s laboratory (Center for Excellence in Vascular Biology) at Harvard Medical School. His research focuses on the influence of biomechanical force on endothelial phenotypic modulation and its role on pathogenesis of atherosclerosis. He has developed an in vitro system to recreate arterial shear stress waveforms acquired from atherosclerosis-susceptible and -resistant regions of human vasculature, and studied endothelial functions under these conditions. Using this system, combined with genome-wide transcriptional profiling strategies, his work has revealed distinct global gene expression patterns and some of the underlying molecular mechanisms that are responsible for the disease-prone and –protected phenotypes of vascular endothelium.
Guohao’s education and research experiences concentrate in the field of cardiovascular biomechanics and vascular biology. He is a member of Biomedical Engineering Society and North American Vascular Biology Society. He serves as a reviewer for National Science Foundation, American Heart Association, Journal of Biomechanical Engineering, American Journal of Physiology, Cell and Molecular Bioengineering, Cardiovascular Bioengineering, Tissue Engineering and Journal of Vascular Surgery.